A Synergistic Antibacterial Platform Combining Low–Temperature Photothermal Therapy and Antibiotic Therapy

Antimicrobial resistance has brought great burden to global public health. Alternative strategies are needed reduce the development of drug resistance. Herein, we have developed an effective synergistic antibacterial strategy combining low–temperature photothermal therapy (LT–PTT) with antibiotic therapy, improving bactericidal efficiency avoid antimicrobial Copper sulfide templated bovine serum albumin (CuS–BSA) nanoparticles were selected as agent, and co–loaded into hydrogel (Gel) mupirocin. The Gel could slow down release rate CuS–BSA mupirocin, thereby prolonging reaction time. More importantly, when applying near–infrared laser irradiation, activity platform be enhanced greatly by LT–PTT effect nanoparticles. In vitro in vivo results both confirmed that efficacy therapeutic was improved complete bacterial removal. Overall, this posed a potential improve patient compliance.